Why does aspirin pass through the stomach unchanged but is readily hydrolyzed in the intestinal tract?

in Hydrolyze Reviews

The stomach or rather the intestinal tract that makes this happen.

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ADITYA V January 5, 2011 at 2:13 am

In the intestine there is alkaline nature, whereas stomoch is acidic

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doctor January 7, 2011 at 5:40 am

This is much less soluble than the ionized form. While the neutral form is actually the form that can be absorbed through the membrane, the surface area of the stomach is extremely small compared to the intestine and is not that well supplied with blood, consequently little aspirin is absorbed in the stomach. However, because it cannot dissolve and because the undissolved aspirin also carries along some of the filler with it.

Once aspirin passes through the stomach into the small intestine, the pH rises to 5.5-6.5. At this pH most of the aspirin deprotonates, becomes ionized, and becomes very soluble. However, there is still a couple of percent of neutral aspirin which can passively move through the membrane and then be absorbed via the portal vein into the blood from whence it goes directly to the liver….

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